The unluckiest one should be the Carefree Demon Emperor.
Previously controlled by the Heaven Devouring Great Emperor, his mind hadn't fully recovered, causing him to react a bit slower than the other three top-tier Immortal Emperors. The Five Elements Origin Qi Cauldron struck him, and after destroying his Emperor's Instruments, it collided with him, leaving him severely injured.
A severely injured Emperor Realm Expert, entering the perilous Endless Space, simply couldn't withstand the tearing force of the intense astral wind.
Therefore, the fate of the Carefree Demon Emperor could well be imagined.
As for the Red Lotus Immortal Emperor and the other three top-tier Immortal Emperors, although their Emperor's Instruments were destroyed and their bodies didn't suffer severe injuries, they wouldn't fare well while escaping from the Endless Space either.
Moreover, since their Emperor's Instruments were destroyed, recreating one wouldn't be easy for them.
